Boron tribromide → HCID 58156887, compound

Participants

Reaction Steps

Methyl 4-[5-(4-isopropylphenyl)-2-oxo-1,3,4-thiadiazol-3(2H)-yl]benzoate (0.20 g, 0.56 mmol) in dichloromethane (10 mL) is then treated with boron tribromide (1M in dichloromethane, 1.7 mL, 1.7 mmol) at room temperature overnight. The volatiles are removed in vacuum and the residue is treated with water. The precipitate is collected and washed thoroughly with water to furnish the desired product, 4-[5-(4-isopropylphenyl)-2-oxo-1,3,4-thiadiazol-3(2H)-yl]benzoic acid (0.19 g, 100%), m.p. 205-208° C. 1H NMR (CDCl3, 300 MHz) δ (ppm) 1.30 (d, 6H) 2.92-3.06 (m, 1H), 7.35 (d, 2H), 7.70 (d, 2H), 8.11-8.23 (m, 4H). (ES+) m/z: 341.

Provenance & Evidence