HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid--N-[(1-{N-[14-amino-1,4,7,10,13-pentahydroxy-5-(2-methylpropyl)-2,8-di(propan-2-yl)-3,6,9,12-tetraazatetradeca-3,6,9,12-tetraen-1-ylidene]-5-hydroxy-5-iminonorvalyl}pyrrolidin-2-yl)(hydroxy)methylidene]glycine (1/1) → Larazotide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid--N-[(1-{N-[14-amino-1,4,7,10,13-pentahydroxy-5-(2-methylpropyl)-2,8-di(propan-2-yl)-3,6,9,12-tetraazatetradeca-3,6,9,12-tetraen-1-ylidene]-5-hydroxy-5-iminonorvalyl}pyrrolidin-2-yl)(hydroxy)methylidene]glycine (1/1) | HCID 44146842 | — |
| Solvent | Water | HCID 962 | — |
| Product | Larazotide | HCID 9810532 | — |
Reaction Steps
Solubilities of Larazotide acetate and the corresponding chloride salt in water were tested at 20° C. after 14 hours of vigorous stirring in the presence of residual solid. Concentrations of peptide are measured by standardized HPLC. The chloride salt is more soluble than the acetate salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09051349B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-1796805bfe664afeab2f1b5ea3d417a8 |
| Source note | uspto-grants-2015_06 |