Hydrochloric Acid → HCID 70873760, compound

Participants

Reaction Conditions

Reaction Steps

1 N hydrochloric acid was added to an ethanol solution of 1-[4-(tetrahydropyran-2-yloxy)phenyl]-4-(5-trifluoromethylbenzofuran-2-ylmethyl)piperidine (2.3 g) and stirred at 80° C. for 1 hour. After being cooled to room temperature, a saturated sodium hydrogen carbonate aqueous solution was added to the mixture and concentrated under reduced pressure. The residue was subjected to extraction with ethyl acetate. The organic layer was dried over sodium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:1) to afford the title compound as a pinkish white amorphous compound (1.15 g).

Provenance & Evidence