tert-Butyl piperazine-1-carboxylate → HCID 70873435, compound

Participants

Reaction Steps

2-Chloro-6-(tetrahydropyran-2-yloxy)quinoline (1.00 g) and piperazine-1-carboxylic acid tert-butyl ester (0.76 g) were heated to 140° C. in the absence of solvent under an argon atmosphere and stirred for 2 hours. After cooling the reaction mixture to room temperature, a sodium hydrogen carbonate aqueous solution was added thereto, followed by extraction with dichloromethane. The organic layer was washed with a saturated sodium chloride aqueous solution and dried over magnesium sulfate. The result was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane:ethyl acetate=75:25→67:33). The result was concentrated to dryness under reduced pressure to afford the title compound as a pale yellow amorphous compound (0.55 g).

Provenance & Evidence