HCID 86709386, compound → HCID 70873613, compound

HRID 2172217Notes

Reaction equation

HRID 2172217 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14]/[CH:15]=[CH:16]/[C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:24])[F:25])=[CH:19][CH:18]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 86709386HCID 86709386, compound

Product 1

HCID 70873613HCID 70873613, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-[(E)-3-(4-Trifluoromethylphenyl)allyl]piperidine-1-carboxylic acid tert-butyl ester (13.4 g, 36.2 mmol) and 10% palladium on carbon (1.4 g, 1.3 mmol) were suspended in ethanol (120 ml), followed by stirring under a hydrogen atmosphere (atmospheric pressure) at room temperature for 5 hours. Thereafter the insoluble matter was removed by filtration, and the resulting solution was concentrated to afford the title compound as a colorless oil (crude).

Workup

  1. customThereafter the insoluble matter was removed by filtration
  2. concentrationthe resulting solution was concentrated

Sources & evidence

ORD record
ord-44a97afdb49e49b29f6362b622ba4693
Source dataset
uspto-grants-2015_06
Patent number
US09051333B2

Reaction notes

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