Triethylamine → HCID 86709391, compound

Participants

Reaction Steps

Triethylamine (2.90 ml, 20.8 mmol) and diphenylphosphorylazide (4.48 ml, 20.8 mmol) were added to a 1,4-dioxane solution (70 ml) of 2-methyl-2-[4-(4-trifluoromethylbenzyloxy)phenyl]propionic acid (7.03 g, 10.8 mmol) and heated at reflux. After 2 hours, the solvent was distilled off, and diethylether and water were added to the residue, followed by extraction with diethylether. The result was washed with water and a saturated sodium chloride aqueous solution and dried over sodium sulfate. After removing the desiccant by filtration, the solvent was distilled off to afford the title compound as a pale brown oil (6.89 g, 99%).

Provenance & Evidence