Sodium Bicarbonate → HCID 86709398, compound

Participants

Reaction Steps

A 1 N HCl ethanol solution (6 ml) was added to (R)-2-nitro-7-(4-{4-[2-(tetrahydropyran-2-yloxy)-2-(4-trifluoromethoxyphenyl)ethyl]piperidin-1-yl}phenoxymethyl)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (0.20 g), and the mixture was stirred at room temperature for 3 hours. A saturated sodium hydrogen carbonate aqueous solution was added to the residue obtained by distilling the solvent off, followed by extraction with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution and dried over sodium sulfate. After filtering, the filtrate was concentrated under reduced pressure. The crystal thus obtained was washed with methylene chloride-ether and dried to afford the title compound as a white powder (0.16 g).

Provenance & Evidence