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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2172278Generated: October 31, 2026

Trifluoroacetic acid → HCID 86709402, compound

https://huagongshe.com/reaction/2172278

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 86709412HCID 86709412—
SolventDichloromethaneHCID 6344—
ProductHCID 86709402HCID 86709402—

Reaction Steps

Trifluoroacetic acid (4 ml) was added to a dichloromethane solution (4 ml) of (2R,5S)-2,5-dimethyl-4-[4-((R)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-7-ylmethoxy)phenyl]piperazine-1-carboxylic acid tert-butyl ester (1.31 g), and the mixture was stirred overnight. The reaction mixture was concentrated under reduced pressure to afford the title compound as a brown amorphous compound (1.35 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09051333B2
Source datasetuspto-grants-2015_06
ORD IDord-ba6b60e7f75d4ad0afab2baaabc17a5d
Source noteuspto-grants-2015_06