反应详情

A solution of 1H-imidazole (6.17 g, 91 mmol) and 5-fluorothiazol-2-amine hydrochloride (Milestone Pharmatech, Brunswick, N.J., 3.50 g, 22.64 mmol) in 100 mL DCM was cooled to −78° C. sulfuryl chloride (1.841 ml, 22.64 mmol) was added, and the reaction mixture was allowed to stir for 10 minutes. The reaction mixture was then transferred to a 0° C. cooling bath, and was allowed to stir for an additional hour. LC/MS showed mostly product, so the reaction mixture was diluted with a small amount of heptane, and the solvent was decanted off. The resulting solid was dried (kept under vacuum) and used without further purification. [M+H]+=249.0

1. additionwas added
2. customwas then transferred to a 0° C.
3. temperaturecooling bath
4. stirringto stir for an additional hour
5. customthe solvent was decanted off
6. customThe resulting solid was dried (kept under vacuum)
7. customused without further purification