反应详情

To a solution of 2,2-dimethyl-pentanedioic acid dimethyl ester (2.40 g, 12.8 mmol) in MeOH (15 ml) is added potassium hydroxide (0.788 g, 14.0 mmol). The mixture is stirred at room temperature for 16 hours and refluxed for 2 hours. The mixture is cooled to room temperature and concentrated under reduced pressure. To the obtained residue, 1M aqueous HCl (14 ml) is added and the solution is extracted with ether. The organic layer is washed with H2O, dried over Na2SO4, and concentrated under reduced pressure to give 2,2-dimethyl-pentanedioic acid 1-methyl ester (1.97 g, 88%); 1H NMR (400 MHz, chloroform-d) ppm 1.20 (s, 6H), 1.87-1.91 (m, 2H), 2.32-2.36 (m, 2H), 3.67 (s, 3H).

1. temperaturerefluxed for 2 hours
2. temperatureThe mixture is cooled to room temperature
3. concentrationconcentrated under reduced pressure
4. additionTo the obtained residue, 1M aqueous HCl (14 ml) is added
5. extractionthe solution is extracted with ether
6. washThe organic layer is washed with H2O
7. dry with materialdried over Na2SO4
8. concentrationconcentrated under reduced pressure