(2-Methoxy-4-(trifluoromethyl)phenyl)boronic acid → HCID 71737064, compound

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Reaction Steps

The title compound was prepared in a manner analogous to Example 1, except that (2-methoxy-4-(trifluoromethyl)phenyl)boronic acid was used in place of (2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)boronic acid and 5-chloro-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2,6-naphthyridine-2(1H)-sulfonamide (Intermediate V) was used in place of 5-bromo-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide. [M+H]+=472.0 1H NMR (400 MHz, Acetone-d6) δ ppm: 8.41 (d, J=5.1 Hz, 1H), 8.25 (s, 1H), 7.35-7.44 (m, 3H), 7.20 (d, J=5.1 Hz, 1H), 4.26-4.51 (m, 2H), 3.89 (s, 3H), 3.43-3.56 (m, 1H), 3.15-3.26 (m, 1H), 2.82-2.93 (m., 1H), 2.40-2.56 (m, 1H)

Provenance & Evidence