2,4-Dimethyl-3-cyclohexene carboxaldehyde → α-Ethyl-2,4-dimethyl-3-cyclohexene-1-methanol

Participants

Reaction Conditions

Reaction Steps

A reaction flask was charged with ethylmagnesium bromide solution (CH3CH2MgBr) (3 M, 2.4 L) in tetrahydrofuran (THF) and cooled to 0° C. 2,4-Dimethyl-cyclohex-3-enecarbaldehyde (905 g) was added slowly while the temperature was kept at 0° C. The reaction mixture was stirred for an additional hour and then quenched with hydrochloric acid (HCl). The reaction mixture was washed with sodium carbonate (Na2CO3) and brine. Further distillation provided 1-(2,4 -dimethyl-cyclohex-3-enyl)-propan-1-ol (1.021 Kg).

Provenance & Evidence