Cornforth reagent → HCID 123347450, compound

Participants

Reaction Steps

Thereafter 2.5 equivalents of PDC (pyridinium dichromate) and 1 equivalent of 5-(2,4,4-trimethylcyclopentylidene)-pentan-1-ol in proportion 68:32 in dichloromethane are placed in the flask. The suspension is agitated vigorously at ambient temperature overnight. When the conversion is satisfactory (>95%), the reaction medium is filtered on Celite® and then on silica. The filtrate thus obtained is washed with an aqueous 1% HCl solution and then with a saturated aqueous sodium bicarbonate solution, and then with water. After drying on magnesium sulfate, filtration on paper and evaporation of the solvent, the crude product, containing two isomers in proportion 68:32 of 5-(2,4,4-trimethylcyclopentylidene)-pentanal, is distilled under reduced pressure: its boiling point is 52° C. at 0.3 torr.

Provenance & Evidence