Cornforth reagent → HCID 123403367, compound

Participants

Reaction Steps

Thereafter 2.5 equivalents of PDC (pyridinium dichromate) and 1 equivalent of 6-(2,4,4-trimethylcyclopentylidene)-hexan-1-ol in proportion 70:30 in dichloromethane are placed in a flask. The suspension is agitated vigorously at ambient temperature overnight. When the conversion is satisfactory (>95%), the reaction medium is filtered on Celite® and then on silica. The filtrate thus obtained is washed with an aqueous 1% HCl solution and then with a saturated aqueous sodium bicarbonate solution, and then with water. After drying on magnesium sulfate, filtration on paper and evaporation of the solvent, the crude product, containing two isomers in proportion 70:30 of 6-(2,4,4-trimethylcyclopentylidene)-hexanal, is distilled under reduced pressure: its boiling point is 59° C. at 0.2 torr.

Provenance & Evidence