Hydrochloric Acid → HCID 71224338, compound

Participants

Reaction Conditions

Reaction Steps

A solution of Example 1A (2.0 g, 7.45 mmol) in a solvent mixture of ethanol (24.84 ml) and 10% HCl solution (4.53 ml, 14.91 mmol) was heated to 50° C. for 18 hours. The reaction mixture was cooled, and the majority of the ethanol removed by rotary evaporation. The residue was partitioned between ethyl acetate and water. The layers were separated, and the aqueous layer was extracted with additional ethyl acetate. The combined organics were dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to provide the title compound, which was used in the subsequent step without further purification. MS ESI(+) m/z 241 [M+H]+.

Provenance & Evidence