Cyclobutylamine → HCID 71224013, compound

Participants

Reaction Steps

A mixture of Example 158C (100 mg, 0.2 mmol), cyclobutanamine (30 mg, 0.4 mmol) and NaCNBH3 (13 mg, 0.2 mmol) in dioxane (5 mL) was heated at 70° C. for two days. The volatiles were removed, and the residue was purified by HPLC (Zorbax C-18, Mobile phase A: 0.1% TFA in H2O; B: 0.1% TFA in CH3CN; 0-100% gradient) to provide the title compound. MS (DCI/NH3) m/z 529 (M+H)+.

Provenance & Evidence