化工社化工社 化学情報印刷レポート · 研究参考用
1,4-Dioxane → Ethyl 4-formyl-2-(methylthio)pyrimidine-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | Ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate | HCID 188208 | — |
| 生成物 | Ethyl 4-formyl-2-(methylthio)pyrimidine-5-carboxylate | HCID 86676023 | — |
反応手順
A solution of ethyl 4-methyl-2-(methylthio)pyrimidine-5-carboxylate in dioxane (330 mg, 1.56 mmol) was treated with SeO2 (220 mg, 2.0 mmol) at 100° C. for 3 days. After cooling, the reaction mixture was concentrated and the residue was purified by flash chromatography (20% ethyl acetate in hexane) to provide the title compound. MS (DCI/NH3) m/z 227 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09051327B2 |
| 出典データセット | uspto-grants-2015_06 |
| ORD ID | ord-de244446aedd4035a0e63df3502447fe |
| 出典メモ | uspto-grants-2015_06 |