HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → 7-benzyl-4-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 10488479 | HCID 10488479 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 7-benzyl-4-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2-amine | HCID 10610087 | — |
Reaction Steps
Thus, for example, J. Med. Chem. 2000, 43, 3837-3851 describes the cyclization of 4-chloro-5-(2-chloroethyl)-6-methylpyrimidine-2-amine with benzylamine in the presence of triethylamine and n-butanol to give 7-benzyl-4-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09055743B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-cac423f38cfe42119b193ab54d49dfd8 |
| Source note | uspto-grants-2015_06 |