Lithium Hydroxide → Linagliptin

Participants

Reaction Steps

Pure Linagliptin is isolated from Linagliptin-D-(−)-tartrate using water and a suitable base. The Linagliptin-D-(−)-tartrate solution is treated with a suitable base such as lithium hydroxide, sodium hydroxide, potassium hydroxide or the like. The base may be added in the form of a solution having about 1% to about 20% concentration. The resulted solution is treated with a water immiscible organic solvent and the organic layer containing linagliptin is separated and is washed with water and concentrated to produce pure Linagliptin.

Provenance & Evidence