Hydrochloric Acid → (3R)-Piperidin-3-amine--hydrogen chloride (1/2)

Participants

Reaction Conditions

Reaction Steps

(R)-piperidine-3-amine dibenzoyl-D-tartrate (9.0 gm) and isopropanol (50 mL) were charged in a 500 mL round bottomed flask equipped with a mechanical stirrer and water (4.5 mL) was added. The mixture was stirred for 30 minutes at 26° C. and IPA.HCl (18%, 12 mL) was added and the resulted mixture was heated to 62° C. and maintained for 2 hours at 62° C. Reaction mixture was allowed to get 26° C. and stirred for 20 hours at 26° C. The precipitation formed was filtered and washed with 9 mL of IPA. The solid was dried under vacuum at 70° C. to get 2.1 gm of pure (R)-piperidine-3-amine dihydrochloride. Chiral Purity: 99.87%, (S)-isomer content: 0.13%.

Provenance & Evidence