Potassium Carbonate → HCID 71582503, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-bromo-2-methyl-3-(2-methyl-5-propynoyl-phenyl)-6-(2-methyl-thiazol-4-ylmethoxy)-3H-pyrimidin-4-one of Step D (64 mg, 0.14 mmol) in acetonitrile (1 mL) was added 2-hydroxy-2-methylpropionamidine HCl (30 mg, 0.21 mmol) and potassium carbonate (60 mg, 0.42 mmol) and the slurry was heated at 75° C. for two hours and at ambient temperature for eighteen hours. The reaction was filtered to remove excess salts. The filtrate was concentrated and purified via normal phase chromatography (ethyl acetate/heptane) to provide the title compound as a white solid (30 mg, 39% yield). MS (M, M+2): 542, 544; 1H NMR (400 MHz, chloroform-d) δ ppm, 1.64 (s, 6H), 2.16 (s, 3H), 2.21 (s, 3H), 2.76 (s, 3H), 5.59-5.67 (m, 2H), 7.26 (s, 1H), 7.54-7.58 (m, 2H), 7.92 (s, 1H), 8.14 (d, J=8.61, 1H), 8.78 (d, J=5.48, 1H).

Provenance & Evidence