HRID2172654

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID25953

Cesium fluoride

CsF

HCID123068

1,3-Cyclohexadien-5-yne

C6H4

HCID1518288

Ethyl 3-(4-chloroanilino)-3-oxopropanoate

C11H12ClNO3

PRODUCTS

生成物

结构：CCOC(=O)C(C(=O)Nc1ccc(Cl)cc1)(c1ccccc1)c1ccccc1

HCID60203753

未命名化合物

收率 85%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

The present invention further provides one pot process for C-arylation of ethyl 3-(4-chlorophenylamino)-3-oxo-propanoate (2) using benzyne precursor (1) in presence of CsF and CH3CN to obtain ethyl 3-(4-chlorophenylamino)-3-oxo-2,2-diphenylpropanoate (4) with more than 85% yield (cf scheme 3).