Fumaric Acid → 173334-58-2

Participants

Reaction Conditions

Reaction Steps

Aliskiren i.e. compound of Formula X (1.5 g, 0.003 mol) and fumaric acid (0.15 g, 0.0013 mol) were dissolved in 5% ethanol/acetonitrile (7.5 mL) and heated to 50-55° C. for 15 min. The reaction mixture was allowed to cool slowly to room temperature and stirred for further 12 h. The slurry formed was diluted with 5% ethanol/acetonitrile (7.5 mL) and filtered under nitrogen. The solid was suck dried for 10 minute under nitrogen and dried for 12 h under vacuum at room temperature to afford white solid (0.9 g, 54%).

Provenance & Evidence