Potassium Carbonate → HCID 73296091, compound

Participants

Reaction Steps

To a stirred mixture of 3-oxo-2,3-dihydrobenzo[d]isothiazole-6-carboxylic acid 1,1-dioxide (8) (1 mmol) and anhydrous K2CO3 (5 mmol) in DMF was added 2-(4-bromobutyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (3b) (3 mmol). The reaction mixture was gently refluxed for overnight, cooled to room temperature and poured into the crushed ice. The resulted solution was acidified with con. HCl and extracted with ethylacetate. The organic layer was washed with water, dried over anhydrous Na2SO4 and concentrated under vacuum to get the crude product. The Crude residue was purified by flash column chromatography using MeOH—CHCl3 (2:8) to obtain the desired product. 1H NMR (400 MHz, DMSO-d6) δ 8.54-8.34 (m, 6H), 7.91-7.77 (m, 3H), 4.41-4.37 (m, 2H), 4.14-4.08 (m, 2H), 1.89-1.71 (m, 4H). MS (ES−) m/z 477 (M−H)−.

Provenance & Evidence