3-Bromoaniline → HCID 19062908, compound

Participants

Reaction Steps

DIEA (433 μL, 2.49 mmol) was added into a suspension of 3-bromobenzenamine (90.3 μL, 0.829 mmol), 4-(piperidin-1-ylmethyl)benzoic acid (200 mg, 0.912 mmol), BOP (477 mg, 1.08 mmol) in DMF (2 mL). The reaction mixture was stirred at room temperature under argon atmosphere overnight. The reaction mixture was loaded onto a 5 g silica loading cartridge. After solvent in the cartridge was dried out under vacuum, the cartridge was put on the ICSO system for purification (yield: 80%). MS (ESI+) m/z 373.0 [M+H]+.

Provenance & Evidence