Hydroxyamine hydrochloride → HCID 178513365, compound

Participants

Reaction Conditions

Reaction Steps

4-Cyano-N-phenyl-benzenesulfonamide (crude) (198 mg, 0.652 mmol), Sodium bicarbonate (547 mg, 6.52 mmol) and NH2OH.HCl (453 mg, 6.52 mmol) was dissolved in EtOH (2172 μL) and the resulting solution stirred overnight at 60° C. The mixture was diluted with EtOAc and water. The water phase was extracted and the combined organic phases washed with brine, then dried over magnesium sulfate. After evaporation of the solvent, 175 mg (0.571 mmol) of a white solid was obtained. The product was used without purification in the next step.

Provenance & Evidence