Hydroxyamine hydrochloride → HCID 178424389, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-cyano-N-o-tolyl-benzenesulfonamide (214 mg, 0.629 mmol) in ethanol (3 mL), hydroxylamine hydrochloride (437 mg, 6.29 mmol) and sodium hydrogen carbonate (528 mg, 6.29 mmol) were added and the resulting suspension was stirred at 60° C. for 18 hrs. Subsequently the reaction mixture was filtered. The precipitate was washed with ethanol and the combined eluents were evaporated under reduced pressure. The residue was dried under high vacuum (45° C., 3 hrs) to give N-hydroxy-4-o-tolylsulfamoyl-benzamidine (345 mg, 0.56 mmol, 89% crude yield, purity 49.6%) as beige solid.

Provenance & Evidence