Imidazole → HCID 57898847, compound

Participants

Reaction Steps

TBDMSCl (5.22 g) was added to a dimethylformamide solution (50 mL) of imidazole (2.83 g) and 2,4-dichloro-5-iodophenol (10 g), which was synthesized according to the production method described in WO 2001/027088. The mixture was stirred at room temperature for 4 hours. Water (150 mL) was added and extracted with hexane (200 mL). The extract was then washed in succession twice with water (100 mL) and once with brine (100 mL), and was pre-dried over anhydrous sodium sulfate, and then filtered. The solvent was distilled off, and the resulting residue was purified by silica gel column chromatography (developing solvent: hexane) to give tert-butyl-(2,4-dichloro-5-iodophenoxy)-dimethyl-silane as pale yellow oil (11.39 g).

Provenance & Evidence