Cesium carbonate → HCID 57898798, compound

Participants

Reaction Steps

Cesium carbonate (12 mg) was added to a dimethylformamide solution (1 mL) of 5-(4-amino-6-benzylsulfanyl-[1,3,5]triazin-2-yl)-2,4-dichlorophenol (11 mg) obtained in Step 4 described above. A solution of α-bromoacetonitrile (3.6 mg) in dimethylformamide (0.2 mL) was added, and the resulting mixture was stirred at room temperature for 3 hours. After dilution with ethyl acetate (7 mL), the mixture was washed in succession twice with water (6 mL) and once with brine (3 mL). The mixture was then pre-dried over anhydrous sodium sulfate and filtered. The solvent was distilled off. The resulting residue was purified by silica gel column chromatography (developing solvent: hexane:ethyl acetate=8:2) to give [5-(4-amino-6-benzylsulfanyl-[1,3,5]triazin-2-yl)-2,4-dichlorophenoxy]-acetonitrile (11 mg) as white solid.

Provenance & Evidence