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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2172815Generated: November 1, 2026

4-Ethynylheptan-4-ol → Tert-butyl 3-fluoro-3-(3-(3-hydroxy-3-propylhex-1-ynyl)phenyl)propylcarbamate

https://huagongshe.com/reaction/2172815

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Ethynylheptan-4-olHCID 12383898—
ReactantTert-butyl 3-(3-bromophenyl)-3-fluoropropylcarbamateHCID 66743475—
ProductTert-butyl 3-fluoro-3-(3-(3-hydroxy-3-propylhex-1-ynyl)phenyl)propylcarbamateHCID 66743011—

Reaction Steps

Sonogashira coupling of tert-butyl 3-(3-bromophenyl)-3-fluoropropylcarbamate and 4-ethynylheptan-4-ol following the method described in Example 12 gives tert-butyl 3-fluoro-3-(3-(3-hydroxy-3-propylhex-1-ynyl)phenyl)propylcarbamate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09056849B2
Source datasetuspto-grants-2015_06
ORD IDord-66036d19516c41b4b41bdf4caa8db25d
Source noteuspto-grants-2015_06