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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2172825Generated: November 2, 2026

4-Ethynylheptan-4-ol → 2-(2-(3-(3-Hydroxy-3-propylhex-1-ynyl)benzyloxy)ethyl)isoindoline-1,3-dione

https://huagongshe.com/reaction/2172825

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Ethynylheptan-4-olHCID 12383898—
Reactant2-(2-(3-Bromobenzyloxy)ethyl)isoindoline-1,3-dioneHCID 66743874—
Product2-(2-(3-(3-Hydroxy-3-propylhex-1-ynyl)benzyloxy)ethyl)isoindoline-1,3-dioneHCID 66743283—

Reaction Steps

Sonogashira coupling of 2-(2-(3-bromobenzyloxy)ethyl)isoindoline-1,3-dione and 4-ethynylheptan-4-ol following the method described in Example 12 gives 2-(2-(3-(3-hydroxy-3-propylhex-1-ynyl)benzyloxy)ethyl)isoindoline-1,3-dione.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09056849B2
Source datasetuspto-grants-2015_06
ORD IDord-a655d28556eb49239e4b66b52c56e6a2
Source noteuspto-grants-2015_06