Hydrochloric Acid → HCID 49788293, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ester 59 (221 mg, 0.71 mmol) in 1:1 H2O/EtOH (9 mL), 4M aq NaOH (10 eq) was added and the reaction mixture was stirred at 100° C. for 1 h. After cooling to rt, the solution was acidified with 2M HCl yielding 5-(2-amino-pyrimidin-4-yl)-2-phenyl-furan-3-carboxylic acid as a white solid which was filtered, washed with water and dried under reduced pressure (quant.).

Provenance & Evidence