反应详情

A solution of 2-chloro-4-(pyridin-2-yl)pyrimidine (0.576 g, 3 mmol), N-(piperidin-4-yl)methanesulfonamide (0.64 g, 3.6 mmol) and Et3N (0.77 mL, 6 mmol) in CH3CN (15 mL) was refluxed for 2 h and TLC (petroleum:EtOAc=5:1) showed the reaction was complete. The reaction mixture was concentrated and purified by chromatography, eluted with CH2Cl2:MeOH (10:1 to 5:1) to give the title compound (0.78 g, 78%) as a yellow oil.

1. concentrationThe reaction mixture was concentrated
2. custompurified by chromatography
3. washeluted with CH2Cl2:MeOH (10:1 to 5:1)