Triethylamine → HCID 67508055, compound

Participants

Reaction Steps

To a solution of 3-chloro-6-(piperazin-1-yl)-2,2′-bipyridine (197 mg, 0.717 mmol) in CH2Cl2 (7 mL) was added methanesulfonylchloride (0.0820 mL, 0.789 mmol) followed by triethylamine (0.110 mL, 0.789 mmol) and stirred at RT for 2 h. The reaction mixture was diluted with H2O (30 mL) and extracted with dichloromethane (2×30 mL), dried over sodium sulfate, and concentrated under reduced pressure. The crude mixture was purified by column chromatography (10-50% ethyl acetate/heptane) and obtained the title compound as a white solid (68 mg, 26% yield). LCMS (M+H)+: 365.0.

Provenance & Evidence