Hydrochloric Acid → HCID 67508395, compound

Participants

Reaction Steps

To a suspension of tert-butyl [1-(3-chloro-3′,5′-dimethyl-2,2′-bipyridin-6-yl)piperidin-4-yl]carbamate (220 mg, 0.528 mmol) in MeOH (5.28 mL) was added HCl (2.64 mL, 4M in dioxane, 2.64 mmol). The resulting yellow solution was stirred at rt for 4 h and concentrated to get 242 mg (99%) of the title compound as a yellow solid. m/z (APCI+) for C17H21N4Cl 317.20 (M+H)+. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.65 (s, 1H) 8.30 (br. s., 3 H) 8.28 (br. s., 1 H) 7.84 (d, J=9.09 Hz, 1 H) 7.14 (d, J=9.35 Hz, 1 H) 4.29 (d, J=13.39 Hz, 2 H) 3.22-3.34 (m, 1 H) 2.95 (t, J=12.25 Hz, 2 H) 2.48 (s, 3 H) 2.24 (s, 3 H) 1.96 (d, J=10.86 Hz, 2 H) 1.48-1.60 (m, 2 H).

Provenance & Evidence