Sodium Hydroxide → HCID 25232947, compound

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Reaction Steps

Using the general procedure described above, the reaction of 10 (80 mg, 0.20 mmol) and 1 N NaOH provided 40 mg of AAG106 as an off-white solid in 64% yield. TLC Rf 0.30 (chloroform-methanol 15:1); mp 208.9-209.1° C.; 1H NMR (DMSO-d6) δ 3.76 (s, 3H, OCH3), 6.19 (s, 2H, NH2, exch), 7.09-8.05 (m, 8H, Ar—H), 8.26 (s, 1H, 4-NH, exch), 11.27 (s, 1H, 9-NH, exch). Anal. Calculated (C17H15N5O. 0.35 CH3OH): C, 65.83; H, 5.22; N, 22.12. Found: C, 66.08; H, 5.22; N, 21.81.

Provenance & Evidence