HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(5-Bromopyrimidin-2-yl)cyclopropanamine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | tert-butyl N-[1-(5-bromopyrimidin-2-yl)cyclopropyl]carbamate | HCID 67508268 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(5-Bromopyrimidin-2-yl)cyclopropanamine dihydrochloride | HCID 68379480 | — |
Reaction Steps
[1-(5-Bromo-pyrimidin-2-yl)-cyclopropyl]-carbamic acid tert-butyl ester (1.18 g, 3.76 mmol) is dissolved in CH2Cl2 (5 mL) at room temperature. A 4M solution of HCl in dioxane (9.4 mL, 38 mmol) is added. After 2 hours, solvents are removed by a stream of N2 to afford crude title compound as a solid, which is used without purification (ES+ m/z 216.3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09056858B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-6360d25c96c641328020d7c734517e23 |
| Source note | uspto-grants-2015_06 |