Sodium borohydride → HCID 68908782, compound

Participants

Reaction Steps

Calcium chloride (0.33 g, 3 mmol) and sodium borohydride (0.23 g, 6 mmol) were added to a mixture (0.80 g, 3 mmol) of methyl 2-methoxycarbonylmethyl-4-cyano-5-chlorobenzoate and methyl 2-methoxycarbonylmethyl-4-cyano-3-chlorobenzoate in a mixed solution (1:1, 10 mL) of ethanol and tetrahydrofuran. The resulting mixture was stirred at room temperature overnight. Water was added to the reaction solution, and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give a 0.6:1 mixture (0.57 g, 89%) of the title compound and 2-chloro-3-(2-hydroxyethyl)-4-hydroxymethylbenzonitrile.

Provenance & Evidence