Methanol → HCID 52916890, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(1-{[1-(4-fluoro-phenyl)-1H-pyrazolo[3,4-c]pyridine-4-carbonyl]-amino}-cyclopropyl)-benzoic acid methyl ester (70.0 mg, 0.163 mmol) in a 2M solution of methylamine in methanol (3.0 mL, 6.0 mmol) is stirred at 90° C. in a sealed pressure tube. After 18 hours, the reaction vessel is cooled to room temperature, vented and opened. The reaction mixture is concentrated in vacuo. The residue is purified by silica gel chromatography eluting with a gradient of 0-8% methanol in methylene chloride to afford the title compound as a solid.

Provenance & Evidence