反应详情

Di-tert-butyl (1S,2R,3S,4S,5R,6R)-2-[(tert-butoxycarbonyl)amino]-3-[(3,4-dichlorobenzyl)oxy]-4-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylate (5.30 g, 9.01 mmol) is added to water (30.02 mL) and acetic acid (30.02 mL). Heat the reaction at reflux until the complete consumption of the starting material. Cool and concentrate on a rotary evaporator. Triturate the concentrate with diethyl ether, collect the precipitate, then dry in a vacuum oven to give the title compound (3.30 g, 8.77 mmol, 97%). MS (m/z): 376/378 (M+1).

1. temperatureHeat
2. customthe reaction
3. temperatureat reflux until the complete consumption of the starting material
4. temperatureCool
5. concentrationconcentrate on a rotary evaporator
6. customTriturate the
7. concentrationconcentrate with diethyl ether
8. customcollect the precipitate
9. customdry in a vacuum oven