Hydrochloric Acid → HCID 86695986, compound

Participants

Reaction Steps

Add bis({[(1-methylethoxy)carbonyl]oxy}methyl) (1S,2R,3S,4S,5R,6R)-2-[(tert-butoxycarbonyl)amino]-3-[(3,4-dichlorobenzyl)oxy]-4-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylate in a 4.0M solution of hydrogen chloride in dioxane (14.47 mL, 57.87 mmol) and stir for 45 minutes. Add ethyl acetate, and concentrate the reaction mixture to a foam. Triturate the foam with ethyl acetate to produce a solid. Concentrate and dry under vacuum at 40° C. overnight to provide the title compound as an off-white solid (1.77 g, 2.75 mmol, 95%): MS (m/z): 608 (M+H).

Provenance & Evidence