反应详情

温度

-5 °C

To a 12-L 4-neck cylindrical jacketed vessel equipped with an overhead stirrer, J-KEM thermocouple, and an addition funnel, was charged a solution of cis-cyclohexane-1,2-diamine (500.0 g, 4.378 mole) in EtOH (2.5 L) under nitrogen. The vessel was cooled to −5° C. Ethyl trifluoroacetate (521 mL, 1.00 eq, Acros lot #A0267844) was charged to the addition funnel and was added dropwise to the reaction mixture over a period of 1 hour and 45 minutes to afford the title compound in EtOH, which was carried forward into the next step.

1. customTo a 12-L 4-neck cylindrical jacketed vessel equipped with an overhead stirrer
2. additionwas added dropwise to the reaction mixture over a period of 1 hour and 45 minutes