Triethylsilane → HCID 86727252, compound

Participants

Reaction Steps

4,6-Dichloro-2-(2,4-dimethoxybenzyl)-7-fluoro-1-methyl-1H-pyrrolo[3,4-c]pyridin-3(2H)-one (14.0 g, 36.4 mmol) was dissolved in TFA (70 mL) and triethylsilane (5.1 g, 43.7 mmol). The mixture was heated to reflux and additional triethylsilane (1.3 g, 10.9 mmol) was added until the red-colored solution became clear. TFA and triethylsilane were removed under reduced pressure. The mixture was basified with aq. NaHCO3 to pH 7 and filtered to give the title compound (7.3 g, 85%). 1H NMR (DMSO-d6, 400 MHz) δ ppm 1.42 (d, J=6.8 Hz, 3H), 4.92 (q, J=6.8 Hz, 2H), 9.25 (s, 1H). [M+H] calc'd for C8H5C12FN2O, 235. found, 235.

Provenance & Evidence