Hydrochloric Acid → HCID 71164946, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 6-(((1R,2S)-2-((tert-butoxycarbonyl)amino)cyclo-hexyl)amino)-7-fluoro-4-(5-methylpyrazolo[1,5-a]pyridin-3-yl)-3-oxo-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate (110 mg, 0.185 mmol) in isopropanol (10 mL) at 65° C. was added concentrated HCl (0.268 mL, 3.21 mmol) dropwise. The reaction mixture was stirred at 65° C. overnight and then slowly cooled. The solids were filtered and dried to give an HCl salt of the title compound as a pale yellow solid (75 mg, 94%). 1H NMR (500 MHz, DMSO-d6) δ ppm 1.49 (br s, 1H) 1.61-1.82 (m, 1H) 1.96 (d, J=8.79 Hz, 1H) 2.44 (s, 3H), 4.33-4.45 (m, 2H) 6.81 (d, J=6.35 Hz, 1H) 6.88 (dd, J=7.02, 1.83 Hz, 1H) 7.90 (br s, 2H) 8.20 (s, 1H) 8.37 (s, 1H) 8.66 (d, J=7.02 Hz, 1H) 9.33 (s, 1H). [M+H] calc'd for C21H23FN6O, 395. found, 395.

Provenance & Evidence