tert-Butyl piperazine-1-carboxylate → HCID 67517481, compound

Participants

Reaction Steps

The crude (4-iodo-1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetaldehyde (1.2 g) was dissolved in DCM (40 mL). Boc-piperazine (1.1 g, 5.9 mmol) was added into the solution, followed by addition of sodium triacetoxyborohydride (4.2 g, 20 mmol). The reaction was allowed to stir at RT overnight. The reaction was diluted with DCM, washed with sodium bicarbonate and brine, dried over MgSO4, and purified by silica gel chromatography to furnish tert-butyl-4-[2-(4-iodo-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazine-1-carboxylate. LC-MS (IE, m/z): 473 [M+1]+.

Provenance & Evidence