HCID 67515653, compound → HCID 86692996, compound

HRID 2173127Notes

Reaction equation

HRID 2173127 reaction equation
[ClH:1].CC1C2COC(=O)C=2C=CC=1[CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.Br[C:22]1[CH:31]=[CH:30][C:25]2[C:26](=[O:29])[O:27][CH2:28][C:24]=2[C:23]=1[C:32]([F:35])([F:34])[F:33]>>[ClH:1].[N:15]1([CH2:14][CH2:13][C:22]2[CH:31]=[CH:30][C:25]3[C:26](=[O:29])[O:27][CH2:28][C:24]=3[C:23]=2[C:32]([F:35])([F:34])[F:33])[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 67515653HCID 67515653, compoundHCID 675172294-methyl-5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride

Product 1

HCID 86692996HCID 86692996, compound

Procedure

5-[2-(piperazin-1-yl)ethyl]-4-(trifluoromethyl)-2-benzofuran-1(3H)-one hydrochloride was prepared in an analogous fashion to that described for the synthesis of 4-methyl-5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride above starting from 5-bromo-4-(trifluoromethyl)-2-benzofuran-1(3H)-one. LC-MS (IE, m/z): 315 [M+1]+;

Sources & evidence

ORD record
ord-b0ed7d801b9246199c547178004b9ae1
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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