HCID 89754606, compound → HCID 86692998, compound

Participants

Reaction Steps

To a solution of tert-butyl-4-[2-(1-oxo-4-vinyl-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazine-1-carboxylate (30 mg, 0.081 mmol) in MeOH (10 mL) was added palladium on carbon (4.3 mg, 0.040 mmol). The mixture was allowed to stir under an atmosphere of hydrogen for 16 hours. LC showed complete reaction. The crude reaction was filtered through a pad of Celite®, concentrated to deliver tert-butyl-4-[2-(4-ethyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazine-1-carboxylate.

Provenance & Evidence