Potassium Phosphate, Tribasic → HCID 86692999, compound

Participants

Reaction Conditions

Reaction Steps

To a microwave tube charged with tert-butyl-4-[2-(4-iodo-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazine-1-carboxylate (100 mg, 0.21 mmol) and a stir bar was added palladium acetate (3.6 mg, 0.016 mmol), tricyclohexylphosphine (8.9 mg, 0.032 mmol), cyclopropyl boronic acid (27 mg, 0.32 mmol), and potassium phosphate (160 mg, 0.74 mmol). The tube was sealed, and injected toluene (2 mL) and water (100 uL). The mixture was purged three times with nitrogen, and heated to 100° C. for 30 minutes. LC showed formation of the desired product. The reaction was purified by silica gel chromatography to afford tert-butyl-4-[2-(4-cyclopropyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazine-1-carboxylate. LC-MS (IE, m/z): 387 [M+1]+.

Provenance & Evidence