反应详情

tert-Butyl-4-[2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazine-1-carboxylate (800 mg, 2.1 mmol, 1.0 eq) was treated with 4 N HCl in dioxane (4 mL). The reaction was stirred at r.t. for 3 h and then concentrated. The product was dried under high vacuum pump for 6 hr. The intermediate is often converted to the corresponding free base prior to use by partitioning between saturated Na2CO3 solution and CHCl3-IPA (3:1). LC-MS (IE, m/z): 277.1 [M+1]+; tR=0.4 min.

1. concentrationconcentrated
2. customThe product was dried under high vacuum pump for 6 hr
3. customby partitioning between saturated Na2CO3 solution and CHCl3-IPA (3:1)