tert-Butyl piperazine-1-carboxylate → HCID 86693002, compound

HRID 2173169Notes

Reaction equation

HRID 2173169 reaction equation
[Cl-:1].[OH:2][CH:3]([C:11]1[CH:20]=[CH:19][C:14]2[C:15](=[O:18])[O:16][CH2:17][C:13]=2[C:12]=1C)[CH2:4][NH+:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1.O1C[CH:23]1C1C=C2C(=CC=1)C(=O)OCC2.N1(C(OC(C)(C)C)=O)CCNCC1>>[ClH:1].[OH:2][CH:3]([C:11]1[CH:12]=[C:13]2[C:14](=[CH:19][CH:20]=1)[C:15](=[O:18])[O:16][CH2:17][CH2:23]2)[CH2:4][N:5]1[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 3

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 66647325HCID 66647325, compoundHCID 77230677HCID 77230677, compound

Product 1

HCID 86693002HCID 86693002, compound

Procedure

6-[1-Hydroxy-2-(piperazin-1-yl)ethyl]-3,4-dihydro-1-H-isochromen-1-one hydrochloride was prepared in an analogous fashion to that described for the synthesis of 1-[2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-ium chloride starting from 6-(oxiran-2-yl)-3,4-dihydro-1H-isochromen-1-one and tert-butyl piperazine-1-carboxylate. LC-MS (IE, m/z): 277 [M+1]+.

Sources & evidence

ORD record
ord-de1f9cac56d548a2862e00334c5216b3
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

Loading…